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    YU Jing, WANG Feng-qin, YAO Wen-juan, WU Dong-mei, ZHANG Wei-qiang, WANG Qin-zeng, PANG Si-yi. Study on the relationship between BRAFV600E mutation and central lymph node metastasis of papillary thyroid carcinoma[J]. Journal of Bengbu Medical University, 2020, 45(4): 493-496. DOI: 10.13898/j.cnki.issn.1000-2200.2020.04.019
    Citation: YU Jing, WANG Feng-qin, YAO Wen-juan, WU Dong-mei, ZHANG Wei-qiang, WANG Qin-zeng, PANG Si-yi. Study on the relationship between BRAFV600E mutation and central lymph node metastasis of papillary thyroid carcinoma[J]. Journal of Bengbu Medical University, 2020, 45(4): 493-496. DOI: 10.13898/j.cnki.issn.1000-2200.2020.04.019
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    Study on the relationship between BRAFV600E mutation and central lymph node metastasis of papillary thyroid carcinoma

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      • Abstract
    • ObjectiveTo analyze the relationship between BRAFV600E mutation and central lymph node(CLN) metastasis of thyroid papillary carcinoma(PTC), and predict the risk factors of CLN metastasis.
      MethodsThe BRAFV600E mutation was detected in 104 PTC cases, and the relationships between the mutation and clinicopathological, ultrasonic characteristics of PTC were analyzed.The risk factors of CLN metastasis were analyzed using single factor and multiple factors methods.
      ResultsBRAFV600E mutation was associated with the maximum diameter of tumor, tumor calcification, extramembrane invasion and CLN metastasis(P < 0.01).The BRAFV600E mutation and extramembrane invasion were the independent factors of CLN metastasis(P < 0.01).
      ConclusionsBRAFV600E mutation can provide the genetic basis for CLN dissection in PTC surgery.
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