Study on transcranial doppler in patients with leukoaraiosis

ObjectiveTo observe the changes of the cerebral blooding flow in patients with leukoaraiosis(LA) using transcranial doppler(TCD).

MethodsOne hundred and two LA patients diagnosed by MRI and 96 normal elders were divided into the LA group and control group, respectively.The LA group was furtherly divided into group according to different lesion degree by Fazkas scale analysis.All cases were examined using TCD, and the flow velocity(Vm) and pulse index(PI) of the bilateral middle cerebral artery(MCA), anterior cerebral artery(ACA), internal carotid artery(ICA), posterior cerebral artery(PCA), vertebral artery(VA) and basilar artery(BSA) was recorded.

ResultsCompared with the control group, the Vm and PI of MCA, ICA, ACA in LA group slowed down and increased, respectively(P < 0.05 to P < 0.01).With the increasing of lesion degree in LA group, the Vm value decreased gradually, and the PI value increased gradually(P < 0.05 to P < 0.01).

ConclusionsThe blood in the white matter area of brain is mainly supplied by the internal system of neck, the cerebral flow decreases, and the cerebral vascular resistance increases in LA patients.With the LA degree increasing, the cerebral perfusion decreases.