Diagnostic value of the detection of HE4, CA125 combined with D-dimer in ovarian cancer

ObjectiveTo explore the value of the detection of carbohydrate antigen 125(CA125), human epididymis protein 4(HE4) combined with D-dimer in the diagnosis of ovarian malignant tumor.

MethodsA total of 122 ovarian malignant tumor patients diagnosed by pathology, 113 benign ovarian tumor patients diagnosed by imaging findings and 121 healthy females at the same tine were divided into the ovarian cancer group, benign ovarian tumor group and control group, respectively.The serum concentrations of HE4, CA125 and D-dimer in three groups were determined, the differences of which among three groups were compared, and the diagnostic significance of the separation and synergy of three indicators was analyzed.

ResultsThe serum levels of CA125 and HE4 in ovarian cancer group, benign tumor group and control group gradually decreased in turn(P < 0.05 to P < 0.01).The differences of the serum level of D-dimer level in ovarian cancer group was higher than that in benign tumor group and control group(P < 0.01), and the difference of which between the benign tumor group and control group was not statistically significant(P>0.05).The differences of the serum levels of D-dimer, CA125 and HE4 in ovarian cancer patients with different clinical stages were statistically significant(P < 0.01).With the increasing of ovarian malignant degree, the serum levels of CA125 and HE4 increased.The serum levels of D-dimer in patients with stages Ⅲ and Ⅳ, Ⅱ, and Ⅰ ovarian cancer gradually decreased, the differences of the serum levels of D-dimer among above patients were statistically significant(P < 0.05 to P < 0.01), and the difference of which between the stage Ⅲ and Ⅳ patients was not statistically significant(P>0.05).In the diagnosis of ovarian cancer, the sensitivities of the detection of D-dimer, CA125 and HE4 were 80.33%, 81.97% and 63.93%, respectively.The sensitivity of the combined detection of three indexes was 94.26%.The AUC of the combined detection of three indexes in the diagnosis of the stageⅠtoⅡ and stageⅠto Ⅳ ovarian cancer were 0.913 and 0.959, respectively, which was significantly higher than that of the single indicator detection.

ConclusionThe combined detection of serum CA125, D-dimer and HE4 can significantly improve the sensitivity and diagnostic efficiency of ovarian cancer, and the expression levels of three indicators are related to the clinical stage of ovarian cancer.