Effect of Shenfu injection combined with ulinastatin in the treatment of sepsis

ObjectiveTo observe the efficacy and safety of Shenfu injection combined with ulinastatin in the treatment of sepsis.

MethodsEighty patients with sepsis were randomly divided into the control group and observation group(40 cases in each group).The control group was treated with routine method, and the observation group was treated with ulinastatin combined with Shenfu injection on the basis of routine method.The changes of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score, sequential organ failure assessment(SOFA) score, levels of blood lactic acid and procalcitonin(PCT) between two groups were compared before and after 12 h, 24 h and 48 h of treatment.The ICU hospitalization days and 28-day mortality rate were compared between two groups.

ResultsThe differences of the scores of SOFA and APACHE Ⅱbetween two groups before and after 12 h of treatment were not statistically significant(P＞0.05), and the scores of SOFA and APACHE Ⅱ in observation group after 24 h and 48 h of treatment were significantly lower than those in control group(P＜0.01).The differences of the levels of blood lactic acid and PCT between two groups before treatment were not statistically significant(P＞0.05), and the levels of blood lactic acid in observation group after 12 h, 24 h and 48 h of treatment were significantly lower than that in control group(P＜0.01).The blood lactic acid level in observation group after 48 h of treatment was significantly lower than that in control group(P＜0.01).The hospitalization days in ICU in observation group was obviously lower than that in control group(P＜0.05).The 28-day mortality in the observation group and control group were 17.5%(7/40) and 27.5%(11/40), respectively, and the difference of which was not statistically significant(P＞0.05).

ConclusionsThe Shenfu injection combined with ulinastatin in the treatment of sepsis can stabilize the disease, improve the symptoms, reduce the scores of APACHE Ⅱ and SOFA, improve microcirculation of patients, shorten the treatment course, and has good effect.