Early evaluation of visual evoked potential in hypoxic ischemic encephalopathy children with visual developmental disorders

ObjectiveTo explore the clinical value of early visual evoked potential(VEP) detection in children with hypoxic ischemic encephalopathy(HIE).

MethodsOne hundred children with HIE were divided into the mild group(37 cases), moderate group(38 cases) and severe group(25 cases) according to the clinical classification standard of HIE, and 30 healthy infants in the same period were set as the control group.The latency and amplitude of flash evoked potential(F-VEP) and pattern evoked potential(P-VEP) were compared among four groups.The incidence rates of strabismus, eye flutter and optic nerve atrophy of eye function abnormalities were compared among three groups of HIE patients.

ResultsThe amplitude of F-VEP and P-VEP in three groups of HIE patients were significantly lower than those in control group(P＜0.01), and which decreased with the increasing of HIE degree(P＜0.01).The latency in three groups of HIE patients were higher than that in control group(P＜0.01), and which increased with the increasing of HIE degree(P＜0.01).The differences of the incidence rates of strabismus, nystagmus, optic nerve atrophy and total incidence rate of ocular lesions among three groups of HIE patients were statistically significant(P＜0.05 to P＜0.01).

ConclusionsEarly VEP detection can accurately evaluate the degree of brain injury and visual impairment of HIE neonates, which is of great significance for early diagnosis, disease evaluation and treatment guidance of HIE neonates.