Value of estrogen and progesterone replacement therapy combined with Liuwei Dihuang pills in the treatment of kidney yin deficiency type premature ovarian failure

ObjectiveTo investigate the clinical significance of estrogen and progesterone replacement therapy combined with Liuwei Dihuang pills in the treatment of kidney yin deficiency type premature ovarian failure.

MethodsOne hundred and sixty-four patients with kidney yin deficiency type premature ovarian failure were dividied into the A, B, C and D groups.The group A(41 cases) was treated with with conventional estrogen and progesterone replacement therapy, the group B(43 cases) was treated with Liuwei Dihuang pills, the group C(40 cases) was treated with estrogen and progesterone combined with Liuwei Dihuang pills, and the group D(40 cases) was treated with no drug.The TCM symptom scores, and serum levels of follicle stimulating hormone(FSH), luteinizing hormone(LH), estrogen(E2) were measured after 3 and 6 cycles of treatment or observation, respectively.

ResultsAfter 3 and 6 cycles of treatment in A, B and C groups, the levels of FSH and LH significantly decreased compared with the group D(P＜0.01), the E2 levels significantly increased compared with the group D(P＜0.01), and the differences of the serum levels of FSH, LH and E2 in A, B and C groups between before and after treatment were statistically significant(P＜0.01).After 3 and 6 cycles of treatment in A, B and C groups, the TCM syndrome scores significantly decreased compared before treatment(P＜0.01).After 3 and 6 cycles of treatment in group D, the levels of FSH and LH decreased, the level of E2 increased, and the differences of the levels of FSH, LH and E2, and TCM syndrome scores between before and after treatment were not statistically significant(P>0.05).The total clinical effective rates in A, B and C groups(more than 75%) were significantly higher than that in group D(17.50%) (P＜0.01), the total effective rate in group C was the highest(82.5%).

ConclusionsBoth estrogen and progesterone, and Liuwei Dihuang pills can effectively improve the sex hormone levels and symptoms of clinical discomfort in patients with kidney yin deficiency type premature ovarian failure, and the combined effect of the two is better, which is worthy of clinical reference.