Value of lymphocyte, C reactive protein combined with peripheral blood neutrophil to lymphocyte ratio in the early diagnosis of COVID-19

ObjectiveTo investigate the clinical application value of the single and combined detection of the neutrophil to lymphocyte ratio(NLR), lymphocyte(LY) and C reactive protein(CRP) in the early diagnosis of corona virus disease 2019(COVID-19).

MethodsFifty-three patients with COVID-19 and 90 patients with other respiratory diseases were divided into the COVID-19 group and control group, respectively.The levels of NLR, LY and CRP between two groups were retrospectively analyzed and compared.The ROC curve was used to analyze the application value of the single and combined detection of NLR, LY and CRP in the early diagnosis of COVID-19.

ResultsThe levels of NLR and CRP in COVID-19 group were higher than those in control group, and the level of LY in COVID-19 group was significantly lower than that in control group(P < 0.01).The area under the ROC curve of the single and combined detection of NLR, LY and CRP in the diagnosis of COVID-19 were 0.610, 0.705, 0.833 and 0.817, respectively.The sensitivities and specificities of the single and combined detection of NLR, LY and CRP in the diagnosis of COVID-19 were 31.0%, 69.8%, 67.9%, 58.5% and 96.7%, 62.2%, 80.0%, 92.2%, respectively.The diagnosis value of the combined detection of NLR, LY and CRP were higher than that of the single detection of NLR, LY and CRP.

ConclusionsThe combined detection of NLR, LY and CRP can increase the specificity and sensitivity of early diagnosis of COVID-19, which can guide the clinical treatment as soon as possible, and improve the cure rate of COVID-19.