Application value of COVID-19 test indexes in assessing the disease severity

ObjectiveTo observe the relationship between the test indexes of patients with corona virus disease 2019(COVID-19) and disease severity, and identify the critical patients early.

MethodsThe data of 86 patients with COVID-19 were collected.The patients were divided into the non-severe group(n=68) and severe group(n=18) according to the severity of illness.The results of laboratory test in two groups were analyzed using SPSS 18.0.software.

ResultsThe differences of the gender, age, and history of residence in Wuhan between two groups were not statistically significant(P>0.05).The lymphocyte count and percentage, and total T lymphocytes, CD4⁺ lymphocytes and CD8⁺ lymphocytes in the T-cell subset of severe group were lower than those of non-severe group, while the levels of lactate dehydrogenase(LDH), C reactive protein, serum amyloid A, and interleukin-6 in severe group were higher than those in non-severe group(P < 0.01).The results of logistic regression analysis showed that the LDH level increasing was a risk factor in the exacerbation of patients with COVID-19, and the CD4⁺ lymphocytes decreasing was the protective factors.

ConclusionsThe changes of many laboratory indexes in patients with COVID are significant, which has some reference value in the assessment of the disease severity, especially for the severe patients with the LDH increasing and CD4⁺ lymphocytes decreasing.