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    HU Ming-chuang, ZHANG Hong-xiang, ZHOU Fa-you, GAO Pan, TANG Xiao-lei. Investigation of the DNA fraction deficiency of sperm mitochondria in infertility patients with varicocele of spermatic cord[J]. Journal of Bengbu Medical University, 2020, 45(6): 809-811. DOI: 10.13898/j.cnki.issn.1000-2200.2020.06.029
    Citation: HU Ming-chuang, ZHANG Hong-xiang, ZHOU Fa-you, GAO Pan, TANG Xiao-lei. Investigation of the DNA fraction deficiency of sperm mitochondria in infertility patients with varicocele of spermatic cord[J]. Journal of Bengbu Medical University, 2020, 45(6): 809-811. DOI: 10.13898/j.cnki.issn.1000-2200.2020.06.029
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    Investigation of the DNA fraction deficiency of sperm mitochondria in infertility patients with varicocele of spermatic cord

      Graphical Abstract
      • Abstract
    • ObjectiveTo analyze the 4977bp sperm mitochondrial DNA(mtDNA) deficiency in patient with varicocele infertility.
      MethodsThe semen samples of 60 infertile patients with clinical varicocele and 90 normal men were collected.The total DNA of all cases were extracted, and the 4977bp sperm mtDNA deficiency was detected using the Gap-PCR.
      ResultsThe 4977 bp DNA deficiency in 81.66% of patients with varicocele infertility and 4.44% of healthy people was identified.The DNA missing frequency in infertile patients with varicocele was more(OR=139.80, 95%CI=40.08-487.30).
      ConclusionsThe varicocele may induce the mtDNA deficiency of sperm and infertility.The 4977 bp mtDNA deficiency of sperm is correlated with the infertility caused byvaricocele.
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