Effect of sevoflurane combined with remifentanil anesthesia on stress response and hemodynamics in patients treated with laparoscopic hysteromyomectomy

ObjectiveTo study the effects of sevoflurane combined with remifentanil anesthesia on stress response and hemodynamics in patients treated with laparoscopic hysteromyomectomy.

MethodsOne hundred patients scheduled by laparoscopic hysteromyomectomy were divided into the observation group and control group according to random number table method (50 cases in each group).The control group was intravenously anesthetized with propofol combined with remifentanil, while the observation group was anesthetized with sevoflurane combined with remifentanil.The differences of stress response and hemodynamic changes at 5 minutes before anesthesia(T₁), 30 minutes after pneumoperitoneum(T₂) and at the end of operation(T₃), cognitive function at 1 day before and after operation, and adverse reactions were compared between two groups.

ResultsAt T₂ and T₃, the levels of cortisol, adrenaline, noradrenaline and blood glucose in observation group were lower than those in control group(P < 0.01), and the heart rate, mean arterial pressure and blood oxygen saturation in observation group were lower than those in control group(P < 0.01).On the first day after operation, the score of mini-mental state examination in observation group was higher than that in control group(P < 0.01), while the completion time of trail making test in observation groupp was shorter than that in control group(P < 0.01).The incidence of adverse reactions in observation group was lower than that in control group(P < 0.05).

ConclusionsThe application of sevoflurane combined with remifentanil anesthesia in patients with laparoscopic hysteromyomectomy can significantly reduce the body's stress response, maintain hemodynamic stability, reduce cognitive impairment, and help to avoid adverse reactions.