Effect of the levels of blood lipid, blood glucose and uric acid on the stage of liver fibrosis in patients with chronic HBV infection

ObjectiveTo investigate the influence of the levels of blood lipid, blood glucose and uric acid on the stage of liver fibrosis in patients with chronic HBV infection.

MethodsThe clinical data of 169 patients with chronic hepatitis B(CHB), which included the age, gender, blood routine examination, liver function, uric acid, blood lipid, blood glucose, prothrombin time, hepatitis B two fifty-fifty, alpha fetoprotein and HBV DNA were collected, and their correlations with the occurrence of liver fibrosis were analyzed.

ResultsThe abnormal rates of total cholesterol(CHO) and low density lipoprotein(LDL) in patients with fibrosis stage < S2(23.91% and 15.22%) were higher than those in patients with fibrosis stage ≥S2(9.68% and 5.19%), respectively (P < 0.05), while the abnormal rates of high density lipoproterin and aplipoprotein A (APOA) in patients with fibrosis stage < S2(10.87% and 3.26%) were lower than those in patients with fibrosis stage ≥ S2(24.68% and 18.18%), respectively(P < 0.05 and P < 0.01).The results of logistic regression analysis showed that AST(OR=1.034, P < 0.05), prothrombin time (OR=1.981, P < 0.01), LDL (OR=0.499, P < 0.01), APOA(OR=0.375, P < 0.05) were the independent predictors of moderate and severe fibrosis in CHB patients.

ConclusionsThe serum lipid level of patients with chronic HBV infection can reflect the severity of liver fibrosis to some extent, while the blood glucose and uric acid levels have no significant predictive significance for the stage of liver fibrosis.