Effect of the sublingual Dermatophagoides farinae drops treatment on the clinical effect and quality of life of patients with allergic rhinitis complicated with atopic cough

ObjectiveTo evaluate the effects of sublingual immunotherapy(SLIT) on clinical efficacy and quality of life of patients with allergic rhinitis(AR) complicated with atopic cough(AC).

MethodsThe clinical data of 96 AR patients complicated with AC, aged 6-55 years, were retrospectively analyzed, and divided into the SLIT group(52 cases) and control group(44 cases).The control group was treated with simple anti-allergic drug, and the SLIT group were additionally treated with SLIT on the basis of control group.The TNSS, DCSS, NCSS, TMS, VAS and RQLQ scores were compared between two groups before treatment and after 1 year and 2 years of treatment.

ResultsCompared with before treatment, the TNSS, DCSS, NCSS, TMS, VAS and RQLQ scores in two groups significantly decreased after 1 year and 2 years of treatment(P < 0.01), and the differences of those in two groups between before and after 1 year and 2 years of treatment were statistically significant(P < 0.01).Compared with after 1 year of treatment, the VAS and RQLQ scores in SLIT group were further improved after 2 years of treatment(P < 0.01 and P < 0.05).The differences of the TNSS, DCSS, NCSS, TMS, VAS and RQLQ scores between two groups before treatment were not statistically significant(P>0.05).After 1 year and 2 years of treatment, the TSS, DCSS, NCSS, TMS, VAS and RQLQ scores in SLIT group were lower than those in control group, and the difference of which were statistically significant(P < 0.05 to P < 0.01).

ConclusionsFor AR patients complicated with AC, the treatment effects of SLIT combined with drugs is more significant than that of drug therapy alone, the improvement of quality of life is more significant.