Study on the improving the quality standard of Yangyin Qingyan Granules

ObjectiveTo improve the quality of Yangyin Qingyan Granule.

MethodsIn Yangyin Qingyan Granule, the Honeysucklein, figwort, licorice, oldenlandia and balloon flower root were iidentided using the thin layer chromatography, and the chlorogenic acid content was measured using HPLC.

ResultsThe results of chromatographic identification showed that chromatographic position of the test sample was consistent with that of the control sample, and the strong specificity and no negative interference were found.The results of high performance liquid chromatography analysis showed that the chlorogenic acid was well linear in the range of 0.236 to 2.360μg, the average recovery rate was 97.79%, and the RSD% was 1.17%.

ConclusionThe method is simple, reliable, good specificity and high reproducibility, which can fully reflect the inner quality of Yangyin Qingyan Granule, and be used to improve the quality control of the preparation.