Comparison of therapeutic effect of biliary stent combined with ¹²⁵I particle implantation and palliative surgery in the treatment of advanced cholangiocarcinoma

ObjectiveTo compare the efficacy of self-expanding metal stent combined with catheter loaded ¹²⁵I particle (SEMS-CL-¹²⁵I) and palliative surgery (PS) in the treatment of advanced extrahepatic cholangiocarcinoma (EHCC).

MethodsPatients with advanced EHCC treated with SEMS-CL-¹²⁵I (SEMS-CL-¹²⁵I group, n=67) or PS (PS group, n 34) were selected.The postoperative complications, hospitalization time, hospitalization expenses and overall survival rate (OS) between the two groups were compared.

ResultsCompared with that before operation, the levels of TBIL, ALT and AST in the two groups decreased at 1, 3 and 6 months after operation, while ALB increased (P < 0.05).The level of ALB in SEMS-CL-¹²⁵I group was significantly higher than that in PS group at 1 month after operation (P < 0.05).There was no significant difference in postoperative complications between the two groups (P>0.05).Compared with PS group, The hospitalization time, hospitalization expenses and OS in SEMS-CL-¹²⁵I group were significantly shorter than those in PS group (P < 0.01), and OS was significantly improved (P < 0.05).Preoperative TBIL, CA19-9, ALB and treatment method were the main factors related to postoperative OS.

ConclusionsCompared with PS, SEMS-CL-¹²⁵I significantly shortens the hospitalization time, reduces the hospitalization expenses and prolongs the survival time of patients with advanced EHCC, which is worthy of clinical promotion and application.