Study on the application of ultrasound measurment of optic nerve sheath diameter in the severe preeclampsia with intracranial pressure increasing

ObjectiveTo investigate the value ment of ultrasound measurment of optic nerve sheath diameter(ONSD) in the severe preeclampsia with intracranial pressure(ICP) increasing.

MethodsForty-four pregnant women with severe preeclampsia and 30 single pregnant women without complications were divided into the observation group and control group, respectively.The MRI and ONSD in observation group were detected, and the observation group was subdivided into the normal ICP group and ICP increasing group according to the MRI results.The ONSD was measured in the control group.The differences of ONSD were compared among three groups.The ROC curve was used to explore the optimal threshold for ONSD detection in severe preepilepsy patients complicated with intracranial pressure increasing.

ResultsThe differences of the systolic blood pressure, diastolic blood pressure, gestational weeks and ONSD values among three groups were statistically significant(P < 0.01), and the systolic blood pressure and diastolic blood pressure in ICP increasing group were significantly higher than those in control group and ICP normal group(P < 0.01).The gestational weeks in control group were significantly higher than that in observation group(P < 0.01).The ONSD values in ICP increasing group and normal group were significantly higher than that in control group(P < 0.01), and which in ICP increasing group was significantly higher than that in ICP normal group(P < 0.01).Under the ONSD measurement method, the AUC was 0.759 (95% CI:0.606~0.913, P < 0.01), the maximum Youden index was 0.497, the ONSD critical value was 4.0 mm, and the sensitivity was 62.2%.

ConclusionsThe ultrasound measurement of ONSD can be used in the diagnosis of severe preepilepsia with ICP increasing, which has certain diagnostic value when ONSD is 4.0 mm.