Diagnostic value of PC, SD, PC/SD and FIB-4 in cirrhotic esophageal varices

ObjectiveTo investigate the clinical value of spleen longitudinal diameter(SD), platelet count(PC), PC/SD and FIB-4 index in predicting the cirrhotic esophageal varices(EV).

MethodsThe clinical data of 134 patients with cirrhosis were collected.The esophageal varices in all patients were examined using gastroscopy.According to the presence or absence of EV, the patients were divided into the EV group and non-EV group, and the EV group was subdivided into the RC (+) group and RC (-) group according to the red color sign(RC) The diagnostic efficacy of PC, SD, PC/SD and FIB-4 in EV were evaluated, and the influencing factors of RC was analyzed.

ResultsThe PC, WBC and PC/SD in EV group were lower than those in non-EV group, and the SD, FIB-4, Child-Pugh score and PT in EV group were higher than those in non-EV group(P < 0.05 to P < 0.01).The areas under the curve predicted by PC, SD, PC/SD and FIB-4 for EV were 0.781, 0.811, 0.811 and 0.715, respectively.The area under the curve predicted by SD and PC/SD for EV was 0.822, the sensitivity was 85.4%, and the specificity was 71.1%.The age in RC (+) group was less than that in RC (-) group, and the SD in RC (+) group was greater than that in RC (-) group(P < 0.05 and P < 0.01).The area under the curve of SD for predicting RC in EV group was 0.705, the cutoff value was 151, the sensitivity was 66.1% and the specificity was 64.5%.

ConclusionsThe PC, SD, PC/SD and FIB-4 have certain clinical value in predicting EV.The combination of PC/SD and SD can better predict.The SD is an independent risk factor for RC in patients with cirrhotic EV.