Effect of bifidobacterium triple viable preparation on the postoperative recovery of patients with upper gastrointestinal perforation

ObjectiveTo investigate the safety and effectiveness of bifidobacterium triple viable preparation in the postoperative recovery of patients with upper gastrointestinal perforation.

MethodsSixty patients with upper gastrointestinal perforation were divided into the observation group and control group by random number table method(30 cases in each group).The control group was treated with early enteral nutrition based on the basic treatment regimen, and the observation group was treated with bifidobacterium triple viable preparation preparation based on the control group.The total white blood cell count(WBC), neutrophil ratio, C-reactive protein(CRP), procalcitonin(PCT), interleukin-6(IL-6), CD3⁺T cells, CD4⁺ T cells, CD8⁺T cells, CD4⁺/CD8⁺ and other indicators were detected in two groups, and the hospital stay and incidence rate of complications were recorded.

ResultsThe differences of the levels of WBC, neutrophil ratio, CRP, PCT, IL-6 and T lymphocyte subsets between two groups before and after 1 and 4 days of surgery were not statistically significant(P>0.05).After 4 days of surgery, the neutrophil ratio and IL-6 level in observation group were lower than those in control group(P < 0.05).After 7 days of surgery, the WBC and neutrophil ratio in two groups basically returned to normal, and the difference of which was not statistically significant(P>0.05), and the levels of CRP, PCT and IL-6 in observation group were lower than those in control group(P < 0.05 to P < 0.01).After 4 and 7 days of operation, the proportions of CD3⁺ T cells and CD4⁺ T cells, and CD4⁺/CD8⁺ in observation group were higher than those in control group(P < 0.05 to P < 0.01), the proportion of CD8⁺ T cells in observation group was significantly lower than that in control group(P < 0.01).The length of hospital stay and incidence rate of complications in observation group were lower than those in control group(P < 0.01 and P < 0.05).

ConclusionsThe bifidobacterium triple viable preparation in the treatment of upper gastrointestinal perforation can strengthen the immunity of patients, reduce systemic inflammatory reaction, enhance intestinal barrier, promote rapid recovery of intestinal function and reduce the incidence of postoperative complications, which is worthy of promotion in clinic.