Effect of rutin on reducing myocardial injury induced by perfluorooctanoic acid exposure in mice

ObjectiveTo explore the protective effects of rutin on myocardial injury induced by perfluorooctanoic acid(PFOA) exposure in mice.

MethodsPFOA was used to establish a model of myocardial injury in mice, and the effects of rutin on the body weight, heart weight, myocardial TG, TC content, serum LDH activity, and oxidative stress indicators(myocardial MDA content, GSH-PX and T-SOD activity) and myocardial morphology were investigated in mice.

ResultsThere was no statistical significance in the weight of 1-2 d mice among all groups(P>0.05).The differences of in the weight of 3- 14 d mice on day 8 to day 14 among all groups were statistically significant(P < 0.05), and the weight of mice in PFOA group was lower than that in PFOA+rutin group, the heart weight of mice in PFOA group and PFOA+rutin group was lower than that in control group after 14 days of intervention, while the heart weight of mice in PFOA+rutin group was higher than that in PFOA group(P < 0.05).After 14 days of intervention, the myocardial TC content and serum LDH activity in PFOA group were higher than those in control group(P < 0.05), the myocardial TG content and serum LDH activity in PFOA+rutin group were lower than those in PFOA group(P < 0.05), and the difference of the myocardial TC content between PFOA group and PFOA+rutin group was not statistically significant(P>0.05).After 14 days of inverention, the myocardial MDA content and in PFOA group was higher than those in control group(P < 0.05), but there was no statistical significance in myocardial GSH-PX activity between PFOA group and the control group(P>0.05), the myocardial MDA content in PFOA+rutin group was lower than that in PFOA group, while the differences of the myocardial MDA content and GSH-PX activity between PFOA+rutin group and PFOA group were not statistically significant(P>0.05).

ConclusionsRutin intervention can ameliorate the myocardial injury induced by PFOA exposure in mice.