Effect of heparin-binding protein level on prognosis of patients with sepsis

ObjectiveTo investigate the effect of serum level of heparin-binding protein (HBP) on the prognosis of patients with sepsis.

MethodsThe serum levels of HBP and procalcitonin (PCT) were measured, and the acute physiology and chronic health (APACHE Ⅱ) and sequential organ failure (SOFA) scores were evaluated in 108 patients with sepsis.According to the prognosis, the patients were divided into survival group (81 cases) and death group (27 cases).Serum HBP and PCT levels, APACHE Ⅱ and SOFA scores were compared between the two groups.The correlations of HBP and PCT levels, APACHE Ⅱ and SOFA scores were analyzed.Logistic regression analysis was used to analyze the risk factors of prognosis in patients with sepsis.

ResultsThe HBP and PCT levels, APACHE Ⅱ and SOFA scores in death group were significantly higher than those in survival group of patients with sepsis (P < 0.01).The HBP level in patients with APACHE Ⅱ score≥15 points was significantly higher than that of patients with APACHE Ⅱ score < 15 points (t=6.13, P < 0.01), and the HBP level in patients with SOFA score ≥5 points was significantly higher than that of patients with SOFA score < 5 points (t=5.64, P < 0.01).The HBP and PCT levels, APACHE Ⅱ and SOFA scores were significantly positively correlated (r=0.793, 0.735, 0.708, P < 0.01).Logistic regression analysis showed that HBP and PCT were independent risk factors of sepsis (P < 0.05).

ConclusionsThe level of HBP in patients with sepsis is significantly increased, which is an independent risk factor of death and can predict the prognosis of patients with sepsis to some extent.