Clinical observation of autogenous platelet-rich gel in the treatment of refractory diabetic foot ulcer

ObjectiveTo observe the clinical efficacy of autologous platelet-rich gel(APG) in the treatment of refractory diabetic foot ulcers(DFU).

MethodsForty-five patients with refractory DFU were randomly divided into the observation group(25 cases) and control group(20 cases).The observation group were treated with, and the control group were treated with traditional surgical dressing change.The ulcer healing rate, ulcer surface reduction rate and healing time between two groups were compared after treatment, and the pathological sections of ulcer tissue in observation group before and after APG were made.

ResultsThe healing rate, reduction rate of ulcer surface and healing time in observation group were 80.00%, (0.48±0.56)cm²/w and (26.7±3.0)d, respectively.The healing rate, reduction rate of ulcer surface and healing time in control group were 24.00%, (0.29±0.09)cm²/w and (50.3±3.7)d, respectively.The healing rate and time in observation group were better than those in control group(P < 0.01), and the difference of reduction rate of ulcer surface between two groups was not statistically significant(P>0.05).After APG was applied in the observation group, the results of pathological section of ulcer surface showed that a small amount of neovascularization and granulation tissue generated.

ConclusionsCompared with traditional surgical dressing change, APG has a good effects on the healing of refractory DFU, which can significantly improve the healing rate, and shorten the healing time of ulcer surface.