Relationship between dynamic monitoring NLR and PLR, and efficacy of first-line chemotherapy and prognosis of advanced lung adenocarcinoma

ObjectiveTo investigate the predictive value of dynamic monitoring the neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in the chemotherapeutic effects and lifetime of lung adenocarcinoma patients.

MethodsThe clinical data of 193 advanced lung adenocarcinoma patients treated with first-line chemotherapy were retrospectively analyzed.The relevant data of patients before chemotherapy, after 2 and 4 cycles of chemotherapy were collected.The curative effects of patients were evaluated, and the NLR and PLR were calculated.The relationship between the dynamic changes of NLR and PLR, and various clinical features, first-line chemotherapy efficacy and overall survival(OS) were analyzed.

ResultsThe levels of NLR and PLR in PD group before and after chemotherapy were higher than those in CR group, PR group and SD group(P < 0.01).In terms of the efficacy of chemotherapy, except for NLR4(P>0.05), the NLR0, NLR0, PLR0, PLR2 and PLR4 were negatively correlated with the efficacy of 2-cycle chemotherapy(P < 0.05 to P < 0.01).The NLR0, NLR2, NLR4, PLR0, PLR2 and PLR4 were negatively correlated with the efficacy of 4-cycle chemotherapy(P < 0.01).The results of Kaplan-Meier survival analysis showed that the OS was significantly correlated with the NLR0, NLR4, PLR0, PLR2, PLR4, efficacy of 2-cycle chemotherapy and efficacy of 4-cycle chemotherapy(P < 0.01).The results of multivariate analysis showed that the NLR0 and PLR4 were the independent risk factors of survival(P < 0.05 and P < 0.01).

ConclusionsThe NLR and PLR are closely related to the efficacy and survival of first-line chemotherapy for advanced lung adenocarcinoma.The NLR before treatment and PLR after 4 cycle chemotherapy are the independent prognostic factors of advanced lung adenocarcinoma patients treated with first-line chemotherapy.