ObjectiveTo explore the application value of the detection of serum myeloperoxidase(MPO) and fractional exhaled nitric oxide(FeNO) in severe asthma phenotyping.
MethodsForty patients with stable bronchial asthma included 20 cases with severe asthma and 20 cases with non-severe asthma.Twenty cases with severe asthma, 20 cases with non-severe asthma and 20 healthy people were divided into the severe asthma group, non-severe asthma group and control group, respectively.The serum level of MPO was detected using enzyme-linked immunosorbent assay, and the FeNO level was detected using FeNO detector.The neutrophilic granulocyte count, eosinophile granulocyte count and IgE level in the peripheral blood were also detected.The levels of serum MPO, FeNO, neutrophilic granulocyte, eosinophile granulocyte and IgE among three groups were compared.
ResultsThe differences of the serum MPO level among three groups were statistically significant(P < 0.01), and the serum MPO level in severe asthma group was significantly higher than that in control group and non-severe asthma group(P < 0.01).The difference of the neutrophil level in peripheral blood among three groups was not statistically significant(P>0.05).The differences of the levels of FeNO and IgE among three groups were statistically significant(P < 0.01), the FeNO level in severe asthma group was significantly higher than that in control group and non-severe asthma group(P < 0.01), and the levels of IgE in non-severe asthma group and severe asthma group were higher than that in control group(P < 0.05 and P < 0.01).There was no statistical significance in the eosinophil level among three groups(P>0.05).
ConclusionsThe serum levels of MPO and FeNO in severe asthma patients increase.The detection of serum MPO and FeNO level is helpful to identify phenotypes in patients with severe bronchial asthma, which has great significance in the individualized treatment of disease.
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