Effect of budesonide combined with high-flow oxygen therapy on nitric oxide and lactate in children with acute respiratory distress syndrome

ObjectiveTo study the effects of budesonide combined with high-flow oxygen therapy on nitric oxide(NO) and lactate in children with acute respiratory distress syndrome(ARDS).

MethodsNinety children with ARDS were randomly divided into the oxygen therapy group and combined group.The oxygen therapy group was treated with transnasal high-flow oxygen therapy, and the combined group was additionally treated with budesonide on the basis of the oxygen therapy group.The levels of PaO₂, PaCO₂, oxygenation index, NO and lactate, and pulmonary function before and after treatment were compared between two groups.

ResultsAfter treatment, the level of PaCO₂, and levels of PO₂ and oxygenation index in two groups significantly decreased and increased compared with before treatment, respectively(P < 0.05 to P < 0.01), and the levels of PaCO₂, PO₂ and oxygenation index in combined group were significantly lower and higher than those in oxygen therapy group, respectively(P < 0.01).After treatment, the levels of NO and lactate in two groups decreased compared with before treatment(P < 0.05), and which in combined group were significantly lower than those in oxygen therapy group(P < 0.01).After treatment, the levels of TV, FEV, FEV1 and PEF in combined group were significantly higher than those in oxygen therapy group(P < 0.01).The effective rate in the combined group and oxygen therapy group was 93.33% and 77.78%, respectively, and the difference of which was statistically significant(P < 0.01).

ConclusionsBudesonide combined with high-flow oxygen therapy in the treatment of children with ARDS has a good effect, which can improve the levels of NO and lactate, and respiratory function.