Expression of ORAOV1 and Vasohibin1 in infiltrating breast carcinoma, and their clinicopathological significance

ObjectiveTo investigate the expression levels of oral cancer overexpressed protein 1(ORAOV1)and vasohibin 1(VASH1)in infiltrating breast carcinoma(IBC), their relationship with each other, and their clinical significance in IBC.

MethodsThe positive expression of ORAOV1 and VASH1 protein in 239 cases of IBC tissue and 100 cases of normal mammary tissue were detected using immunohistochemistry.

ResultsThe positive rates of ORAOV1 and VASH1 protein in IBC tissue and control tissues were 58.2% & 56.9% and 13.0% & 12.0%, respectively, and the expression differences of whose were statistically significant between two groups(P < 0.05).The differences of the positive expression rates of ORAOV1 and VASH1 protein among IBC patients with different degrees of differentiation, lymph node metastasis, tumor size and TNM stage were statistically significant(P < 0.05 to P < 0.01).The positive rate of ORAOV1 protein was positively correlated with the positive rate of VASH1 protein(P < 0.01).The overall survival time of IBC's patients with positive expression ORAOV1 and VASH1 was lower than that of IBC's patients with negative expression of ORAOV1 and VASH1(P < 0.01).The results of multivariate COX regression analysis showed that the positive expression of ORAOV1 and VASH1 protein, tumor size and TNM stages were the independent prognostic factor affecting postoperative survival time of IBC patients.

ConclusionsThe ORAOV1 and VASH1 with abnormally high expression may participate in the occurrence and development of IBC, and promote its infiltration and metastasis.The combined detection of ORAOV1 and VASH1 protein expression in tumor tissues of IBC patients is of great significance for the prediction of development and prognosis.