Effect of the tandem of HA230 and HA330, and single HA230 irrigation on the concentration of paraquat and cytokine changes

ObjectiveTo discuss the effects of the tandem of HA230 and HA330 in the treatment of paraquat poisoning, and know the hemoperfusion removing inflammatory mediators and paraquat capacities.

MethodsFifty-six patients with oral paraquat poisoning were divided into the group A(35 cases)and group B(21 cases), and the group A and group B were treated with HA230 resin hemoperfusion and tandem of HA230 and HA330, respecively.Before and after the first hemoperfusion in two groups, the paraquat concentration were monitored, the data of gender, age, poisoning to the first hemoperfusion time, paraquat poisoning severityindex, liver and kidney and myocardial injury time and blood routine were collected and anllyzed, the relationship between above indictors with prognosis were investagyed, and the clinical efficicay of two kinds of treatments were assessd.The paraquat concentration, human serum interleukin 6(IL-6)content, human serum glutathione peroxidase(GSH-PX)activity, human serum malondialdehyde(MDA)content and serum superoxide dismutase(SOD)activity in two groups before and after perfusion were monitored, and the pathogenesis of MODS in patients with paraquat poisoning, and the abilities to remove inflammatory mediators and paraquat were investigated.

ResultsThe fatality rate in 56 patients with paraquat poisoning was 48%(27 cases).The differences of the paraquat concentration in two groups between before and after perfusion were statistically significant(P < 0.05).The difference of the SOD activity in group A between before and after perfusion was statistically significant(P < 0.01), and the differences of the GSH-PX activity, MDA content and IL-6 content in group A before and after perfusion were not statistically significant(P>0.05).The differences of the SOD activity, GSH-PX activity, MDA content and IL-6 contentin in group B between before and after perfusion were not statistically significant(P>0.05).The differences of the SOD activity, GSH-PX activity, MDA content and IL-6 content in two groups between before and after perfusion were not statistically significant(P>0.05).The MDA and IL-6 contents, and GSH-PX and SOD activities in group A between before and after perfusion were not significantly related to the paraquat concentration.

ConclusionsBlood perfusion can effectively remove paraquat.There is no statistical significance in the effects between HA230, HA330 resin hemoperfusion and single HA230 resin hemoperfusion in the treatment of paraquat poisoning.