Correlation analysis between the serum uric acid/creatinine value ratio and carotid intimal-media thickness in type 2 diabetes patients

ObjectiveTo explore the relationship between the serum uric acid to serum creatinine(SUA/SCr) ratio and carotid intima-media thickness(IMT) for analyzing the significance of the SUA/SCr ratio in the detection of large vascular complications in patients with type 2 diabetes.

MethodsThe clinical data of 127 patients with type 2 diabetes were collected.According to the carotid IMT, the patients were divided into the normal group(group G1), intima thickened group(group G2), stable plaque group(group G3)and unstable plaque group(group G4).The differences of clinical data among four groups were statistically analyzed, and the relationship between IMT and SUA/SCr ratio was analyzed.

ResultsThe differences of the course of diabetes among four groups were statistically significant(P < 0.01).The differences of the levels of glycosylated hemoglobin(HbA1c), serum LDL cholesterol(LDL-C), and serum HDL cholesterol(HDL-C) and SUA/SCr ratio among four groups were statistically significant(P < 0.01).The results of logistic regression analysis of influencing factors of carotid IMT showed that the disease course, and the levels of HbA1c, serum LDL-C and serum HDL-C and SUA/SCr ratio might be the risk factors of IMT(P < 0.05 to P < 0.01), and the HDL-C was a protective factor of IMT(P < 0.01).

ConclusionsThe course of diabetes, HbA1c, LDL-C and SUA/SCr ratio are the risk factors of IMT, while the HDL-C is a protective factor of IMT in patients with type 2 diabetes.The change of SUA/SCr in patients with type 2 diabetes complicated with macrovascular complications is more sensitive than that of SUA.