Study on the correlation between the epidermal growth factor receptor gene mutation and histopathological characteristics in lung adenocarcinoma

ObjectiveTo investigate the correlation between epidermal growth factor receptor(EGFR)gene mutation and histopathology in lung adenocarcinoma(LAC).

MethodsThe paraffin-embedded specimens of 179 patients treated with LAC radical surgery were investigated.The mutation and abundance of EGFR gene in 179 LAC tissues were detected using amplification refractory mutation system(ARMS), and the correlation between the mutation of EGFR gene and clinicopathological characteristics was analyzed.

ResultsAmong 179 patients with LAC, 108(60.34%)cases with EGFR gene mutations were found, and the exon 19 and 21 were the main mutations.The differences of EGFR gene mutations among LAC patients with different age, lymph node metastasis and invasive degree were not statistically significant(P>0.05), and the differences of mutation and abundance of EGFR gene among patients with different gender, smoking status, tumor diameter, clinical stage and histological subtype were statistically significant(P < 0.05 to P < 0.01).

ConclusionsThe EGFR gene mutation is associated with the gender, smoking status, tumor diameter, clinical stage and histological subtype.The EGFR mutation in female, small tumor diameter, nonsmokers, early clinical stage and alveolar LAC patients is high.