Correlations of ambulatory arterial stiffness index with plasma fibrinogen and D-dimer in patients with hypertension

ObjectiveTo investigate the relationship between ambulatory arterial stiffness index(AASI)and plasma fibrinogen(FIB)and D-dimer(D-D)in patients with hypertension.

MethodsAccording to the median value of AASI, 220 patients with hypertension were divided into group A(24 h AASI < 0.52, n=106)and group B(24 h AASI≥0.52, n=114).The levels of FIB and D-D were compared between the two groups.Pearson or Spearman correlation analysis and multiple linear regression analysis were performed.

ResultsThe age, duration of hypertension, systolic blood pressure, total cholesterol, low density lipoprotein cholesterol(LDL-C), FIB and D-D in group A were lower than those in group B(P < 0.05).Pearson or Spearman correlation analysis showed that AASI in patients with hypertension was correlated with age(r=0.231, P < 0.05), duration of hypertension(r=0.685, P < 0.05), systolic blood pressure(r=0.721, P < 0.05), blood urea nitrogen(r=0.113, P < 0.05), total cholesterol(r=0.628, P < 0.05), LDL-C(r=0.666, P < 0.05), FIB(r=0.887, P < 0.05), and D-D(r=0.668, P < 0.05).Multiple linear regression analysis showed that AASI was correlated with duration of disease(β=0.107, P < 0.05), systolic blood pressure(β=0.158, P < 0.05), LDL-C(β=0.102, P < 0.05), FIB(β=0.585, P < 0.05), and D-D(β=0.139, P < 0.05).

ConclusionsAASI in patients with hypertension is correlated with plasma FIB and D-D.Intervening the level of FIB and D-D by medicine may delay or control the progress of atherosclerosis.