Meta analysis of the relationship between polymorphism of LOXL1 gene RS2165241 and susceptibility of stripping syndrome glaucoma

ObjectiveTo investigate the association between the Lysyl oxidase like 1(LOXL1)gene polymorphism(rs2165241)and exfoliation syndrome glaucoma(XFG).

MethodsThe Web of science, Embase, PubMed, CNKI and WanFang websites were searched to look for the association between the LOXL1 gene polymorphism(rs2165241)and XFG.The retrieval time was from the time of databases' establishment to August 2019.The relevant data were extracted by two researchers according to inclusion and exclusion criteria, and Meta analyzed using Stata 10.0 software.

ResultsNineteen literatures and 19 studies were included, which was divided into the XFG group(2 422 cases)and healthy control group(3 549 cases).The results of heterogeneity analysis showed that there was some heterogeneity among studies(P < 0.1).The results of Meta analysis of random effects showed that the LOXL1 gene rs2165241 polymorphism was susceptible to XFG in the general population(TT vs.TC+CC:OR=3.87, 95%CI=2.83-5.29, P < 0.01).The results of subgroup analysis of the overall data showed that there was not statistical correlation between the polymorphism of LOXL1 gene rs2165241 and risk of XFG in Asian population(TT vs.TC+CC:OR=1.74, 95%CI=0.58-5.17, P>0.05), and the polymorphism of LOXL1 gene RS2165241 increased the susceptibility to XFG in Caucasian populations(TT vs.TC+CC:OR=4.25, 95%CI=3.07-5.88, P < 0.01).

ConclusionsThe LOXL1 gene polymorphism(rs2165241)is associated with XFG susceptibility, and the allele T may increase the risk of XFG, especially in Caucasian populations.