Correlation analysis between the ratio of neutrophils to lymphocytes and different levels of albumin in type 2 diabetes mellitus

ObjectiveTo investigate the correlation between the neutrophil-to-lymphocyte ratio(NLR)and different levels of albumin in type 2 diabetes mellitus(T2DM).

MethodsTwo hundred ninety-nine patients with T2DM were divided into the NAU group(n=97), MAU group(n=91)and CAU group(n=111)according to the levels of albumin.The clinical data, NLR and biochemical characteristics in three groups were analyzed.

ResultsThe age, course of disease, and levels of FBG, HbA1c, TC, TG, LDL-C, hs-CRP, Cys-C and NL in MAU group were higher than those in NAU group(P < 0.05 to P < 0.01), but the level of HDL-C in MAU group was lower than that in NAU group(P < 0.05).The age, course of disease, and levels of SBP, FBG, HbA1c, TC, TG, LDL-C, Cr, UA, hs-CRP, Cys-C and NLR in CAU group were higher than those in NAU group(P < 0.05 to P < 0.01), the course of disease, FBG, HbA1c, Cr, UA, hs-CRP and NLR in CAU group were higher than those in MAU group(P < 0.05), and the level of HDL-C in MAU group was lower than that in NAU group(P < 0.05).The results of multivariate logistic regression showed that the course of disease, and levels of SBP, DBP, FBG, TG, LDL-C, Cr, hs-CRP, Cys-C and NLR were the relevant factors of influencing the albuninuria in T2DM.The age, duration, and levels of FBG, HbA1C, TC, HDL-C, Cr and hs-CRP were correlation with NLR(P < 0.05 to P < 0.01).

ConclusionsThe NLR is associate with the severity of albuninuria in T2DM.