Effect of smoking on the clinical indicators and renal pathology of IgA nephropathy

ObjectiveTo investigate the effects of smoking on the clinical indicators and renal pathology of IgA nephropathy.

MethodsThe smoking status of 149 patients with IgA nephropathy was retrospectively analyzed, and its relationship with clinical indicators and renal pathological injury were analyzed.

ResultsAmong 149 IgA nephropathy patients, 30 cases were smokers(smoking group)and 119 cases were non-smokers(non-smoking group).The glomerular filtration rate in smoking group was significantly lower than that in non-smoking group(P < 0.01), and the age, male ratio, and levels of triglyceride, blood glucose and urine β2 microglobulin, α1 microglobulin and 24 h urinary protein in smoking group were higher than those in non-smoking group(P < 0.05 to P < 0.01).The scores of renal interstitial fibrosis and glomerular capillary wall thickening in smoking group were higher than those in non-smoking group(P < 0.05).The results of Pearson correlation analysis showed that the smoking amount was negatively correlated with eGFR(r=-0.219, P < 0.05), and positively correlated with the scores of renal interstitial fibrosis and renal tubular atrophy(r=0.183, 0.187, P < 0.05).

ConclusionsThere is a correlation between smoking and renal function injury in IgA nephropathy patients.The chronic tubular interstitial lesion is the main feature of renal pathology caused by smoking.