Effect of the nimodipine combined with thymopentin in the treatment of HIBD, after intracerebral hemorrhage and its effects on serum levels of TLR4 and RBP4

ObjectiveTo observe the effects of the nimodipine combined with thymopentin in the treatment of hypoxic-ischemic brain damage(HIBD)after intracerebral hemorrhage, and its effect on serum levels of Toll-like receptor 4(TLR4)and retinol binding protein 4(RBP4).

MethodsSeventy-eight patients with HIBD after intra cerebral hemorrhage were randomly divided into the observation group and control group(39 cases in each group).The control group was treated with nimodipine, and the observation group was treated with nimodipine combined with thymopentin.The cerebral edema volume, intracranial pressure, national institutes of health stroke scale(NIHSS) score, Barthel index and cerebral hemodynamic index, and serum levels of TLR4 and RBP4 bewteen two groups were compared before and after 15 days of treatment.

ResultsCompared with before treatment, the cerebral edema volume, NIHSS score, Barthel index, intracranial pressure, and serum levels of TLR4 and RBP4 in two groups were significantly improved after treatment(P < 0.05 to P < 0.01), and the above indexes in observation group were better than that in control group(P < 0.05 to P < 0.01).After treatment, the hemodynamic indexes in observation group were significantly improved compared with those before treatment(P < 0.01), and the difference of the hemodynamic indexes in control group were not statistically significant between before and after treatment(P>0.05).

ConclusionsThe nimodipine combined with thymopentin in the treatment of HIBD after intracerebral hemorrhage has good therapeutic effects, and can reduce the serum levels of TLR4 and RBP4, which is worthy of promotion.