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    GE Yan-lei, LIU Cong-hui, FU Ai-shuang, CUI Zi-yang, ZHANG Wan, XIE Bao-quan, WANG Yuan, WANG Hong-yang, ZHANG Jia-bin. Relationship between serum levels of Caspase-3 and Caspase-9 and clinical phenotypes in COPD elderly patients complicated with snoring syndrome[J]. Journal of Bengbu Medical University, 2021, 46(2): 176-178. DOI: 10.13898/j.cnki.issn.1000-2200.2021.02.010
    Citation: GE Yan-lei, LIU Cong-hui, FU Ai-shuang, CUI Zi-yang, ZHANG Wan, XIE Bao-quan, WANG Yuan, WANG Hong-yang, ZHANG Jia-bin. Relationship between serum levels of Caspase-3 and Caspase-9 and clinical phenotypes in COPD elderly patients complicated with snoring syndrome[J]. Journal of Bengbu Medical University, 2021, 46(2): 176-178. DOI: 10.13898/j.cnki.issn.1000-2200.2021.02.010
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    Relationship between serum levels of Caspase-3 and Caspase-9 and clinical phenotypes in COPD elderly patients complicated with snoring syndrome

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      • Abstract
    • ObjectiveTo investigate the correlations of the serum levels of Caspase-3 and Caspase-9 with clinical phenotypes in chronic obstructive pulmonary disease(COPD)elderly patients complicated with snoring syndrome.
      MethodsThree hundred and twelve elderly patients with COPD were divided into the snoring group and simple group according to the presence or absence of snoring syndrome.The serum levels of Caspase-3 and Caspase-9 were compared between two groups, and the relationships between serum levels of Caspase-3, Caspase-9 and sleep index in COPD elderly patients complicated with snoring syndrome were analyzed.
      ResultsThe serum levels of Caspase-3 and Caspase-9 in snoring group were significantly higher than those in simple group(P < 0.01).The AHI and ODI in snoring group were significantly positively correlated with the serum levels of Caspase-3 and Caspase-9, and the LSaO2 and MSaO2 were negatively correlated with the serum levels of Caspase-3 and Caspase-9(P < 0.01).
      ConclusionsThe high serum levels of Caspase-3 and Caspase-9 are correlated with the low degree of APNEA in elderly COPD patients complicated with snoring syndrome.The higher the serum levels of Caspase-3 and Caspase-9 are, the more severe of sleep disturbance is.
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