ObjectiveTo study the correlations among the expression levels of human epididymal protein 4(HE4), carbohydrate antigen 199(CA199) and human lysophosphatidic acid(LPA) in ovarian cancer, and its clinicopathological features.
MethodsOne hundred and forty patients with ovarian cancer, 120 ovarian benign lesions patients treated with operation and 100 healthy women were divided into the ovarian cancer group, ovarian benign lesion group and healthy control group, respectively.The expression levels of HE4, CA199 and LPA in three groups were detected, the positive expression of HE4, CA199 and LPA between ovarian benign lesion group and ovarian cancer group were compared.The correlation of the HE4, CA199 and LPA with clinicopathological characteristics of ovarian cancer patients, and correlation among the expression of HE4, CA199 and LPA were analyzed.
ResultsThe serum levels of HE4, CA199 and plasma LPA in ovarian cancer group were higher than those in benign ovarian lesion group and healthy control group(P < 0.05), and the positive rates of HE4, CA199 and LPA in ovarian cancer group were higher than those in benign ovarian lesion group(P < 0.01).The expression levels of HE4, CA199 and LPA were not correlated with the pathological type and diameter of ovarian cancer(P>0.05), but which were related to the clinical stage, differentiation degree and lymph node metastasis of ovarian cancer patients(P < 0.01).The expression levels of HE4, CA199 and LPA in patients with stage Ⅲ-Ⅳ, low differentiation and lymph node metastasis were higher.The HE4 level was positively correlated with CA199(r=0.183, P < 0.05), the HE4 level was positively correlated with LPA(r=0.216, P < 0.05), and the CA199 level was positively correlated with LPA(r=0.209, P < 0.05).
ConclusionsThe expression levels of HE4, CA199 and LPA in ovarian cancer patients are high, which are related to the clinical stage, differentiation degree and lymph node metastasis.
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