Analgesic effects of different doses of oxycodone in transabdominal myomectomy and its effect on stress response of patients

ObjectiveTo explore the analgesic effects of different doses of oxycodone on transabdominal myomectomy and its effect on stress response.

MethodsOne hundred and twenty-eight patients with transabdominal myomectomy were divided into the group A(treated with 0.05 mg/kg of oxycodone), group B(treated with 0.10 mg/kg of oxycodone), group C(treated with 0.15 mg/kg of oxycodone)and group O(treated with 0.001 mg/kg of fentanyl)according to the dose of oxycodone(32 cases in each group).The visual analogue scale(VAS)score, restlessness and sedation scale(RASS)score, blood glucose and cortisol levels, and incidence rate of adverse reactions were compared among 4 groups.

ResultsThe VAS scores of group A at T2 and T4, group B at T2 and T3, and group C at T2 to T4 were lower than those of three groups at T1(P < 0.05 to P < 0.01).The RASS scores of group A, group B, group C and group O at T2 to T4 were significantly increased compared with those at T1(P < 0.01).The VAS scores in group A, group B and group C at T1 and T2 were significantly lower than those in group O(P < 0.01), and the RASS scores in group A, group B and group C at T1 were significantly lower than those in group O(P < 0.01).The VAS scores in group B and group C at T1 to T3 were significantly lower than those in group A(P < 0.01), and the RASS score in group C at T1 was significantly lower than that in group A(P < 0.01).The VAS and RASS scores in group C at T1 were lower than those in B group(P < 0.05 and P < 0.01).The blood glucose levels in group A at T2 to T4, group B at T2 to T4 and group O at T1 to T4 were significantly higher than those at T0(P < 0.05 to P < 0.01).The levels of cortisol in A, B, C and O groups at T1 to T4 significantly increased compared with at T0(P < 0.01).The blood glucose and cortisol levels in group A, group B and group C at T1 to T3 were lower than those in group O(P < 0.05 to P < 0.01).The incidence rate of total adverse reactions in group C was higher than that in other 3 groups(P < 0.05).

ConclusionsThe 0.10 mg/kg of oxycodone in transabdominal myomectomy has good analgesic effect, high safety, and can significantly inhibit the stress response of patients.It is worthy of popularization.