Expression level of miR-377 in ovarian cancer tissues, and its relationship with clinicopathological parameters

ObjectiveTo investigate the expression level of miR-377 in ovarian cancer tissues, and analyze the correlation between miR-377 expression, and clinicopathological parameters and prognosis of patients.

MethodsFifty ovarian cancer tissue samples and 50 normal ovarian tissue samples were divided into the ovarian cancer group and control group, respectively.The clinical pathological parameters data were collected.The expression levels of miR-377 in two groups were detected using RT-qPCR, and the relationship between mir-377 expression and relevant clinical pathological parameters in ovarian cancer patients were analyzed.The relationship between mir-377 expression and prognosis was analyzed using survival curve, and the independent risk factors of ovarian cancer prognosis using multivariate COX regression method.

ResultsThe expression level of miR-377 in ovarian cancer group was significantly lower than that in control group(P < 0.01).The expression level of miR-377 in ovarian cancer group was correlated with the TNM stage, clinical stage and metastasis of tumor(P < 0.05 to P < 0.01), and not related to the age and ovarian cancer type of clinicopathological parameters(P>0.05).The 5-year survival rate of patient with low expression of miR-377(55.88%) was significantly lower than that in patients with high expression(75.00%) (P < 0.01).The results of multivariate COX regression analysis showed that the low expression of miR-377 and TNM staging were the independent risk factors of ovarian cancer prognosis(P < 0.01).

ConclusionsThe expression level of miR-377 in the ovarian cancer tissues decreases significantly.The expression levels of miR-377 is related to the TNM stage, clinical stage and pathological grade of ovarian cancer, and the low expression of miR-377 and TNM stage are the independent risk factors of the prognosis of patients with ovarian cancer.