Study on the relationship between carotid artery atherosclerosis and blood homocysteine, and its risk factors in patients with lacunar cerebral infarction

ObjectiveTo investigate the relationship between carotid artery atherosclerosis(CAS) and blood homocysteine(HCY), and its risk factors in patients with lacunar cerebral infarction.

MethodsThe carotid artery ultrasound and serum levels of HCY in 200 patients with lacunar cerebral infarction were detected.According to the results of carotid ultrasound examination and blood HCY level, the patients were grouped, and the risk factors of CAS and their relationship with blood HCY were analyzed using univariate analysis and multivariate logistic regression analysis.

ResultsThe differences of the age, hypertension history, levels of hs-CRP and HCY, baseline SBP and SDP between non-CAS group and CAS group were statistically significant(P < 0.05 to P < 0.01).the serum level of HCY in CIMT plaque group was significantly higher than that in CIMT thickening group and normal group(P < 0.01), and the HCY level in CIMT thickening group was also significantly higher than that in normal group(P < 0.01).The CIMT in low HCY group(0.75±0.10) mm was significantly lower than that in high HCY group(1.26±0.13) mm(P < 0.01).The results of multiple logistic regression analysis showed that the age, hypertension history, hs-CRP and HCY were the independent influencing factors of CAS(P < 0.05 to P < 0.01).

ConclusionsIn addition to age, hypertension and HS-CRP, the blood HCY level also affects the occurrence of CAS.Early assessment and prevention of CAS can be carried out clinically based on these risk factors.