ObjectiveTo assess the relationship between serum endostatin(ES) and coronary artery calcification(CAC) in coronary heart disease(CHD) complicated with type 2 diabetes mellitus(T2DM) patients.
MethodsAmong 115 patients with CHD, 60 cases complicated with T2DM and 55 cases complicated without T2DM were divided into the observation group and control group, respectively.The serum ES levels in two groups were detected using enzyme-linked immunosorbent assay, and the coronary artery calcium score(CACS) scores were obtained using CT.
ResultsThe serum ES level in observation group was significantly higher than that in control group(P < 0.01).The differences of the serum ES levels among the patients with 0, single, double and triple branches lesions in observation group were statistically significant(P < 0.01), while the differences of those in control group were not statistically significant(P>0.05).The CACS in observation group was significantly higher than that in control group(P < 0.01).According to the CACS distribution, the serum ES levels in observation group were higher than that in control group(P < 0.05 to P < 0.01).The optimal cutoff value of ES for CACS >100 points was 69.18 ng/mL, and the sensitivity, specificity, AUC and 95%CI were 62.9%, 75.6%, 0.700 and 0.604 to 0.796, respectively(P < 0.01).The results of multiple logistic regression analysis showed that the ES level was an independent risk factors of significant calcification and obstruct of coronary artery.
ConclusionsThe serum ES level is closely related to the number of coronary artery lesions and the degree of calcification in patients with CHD complicated with T2DM, which may be used as a monitoring index for the progression of coronary atherosclerosis.
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