Study on the correlation between serum levels of mitochondrial fusion protein-2, acetaldehyde dehydrogenase 2 and chronic heart failure

ObjectiveTo investigate the correlation between the levels of mitochondrial fusion protein-2(Mfn2), acetaldehyde dehydrogenase 2(ALDH2) and chronic heart failure(CHF).

MethodsOne hundred and eighty CHF patients and 40 healthy people(control group) were investigated.According to the NYHA heart function classification standard, the CHF patients were divided into the class Ⅱ in 46 cases, class Ⅲ in 63 cases and class Ⅳ in 71 cases.After admission, the results of NT-proBNP and cardiac color Doppler ultrasound were improved, the serum levels of Mfn2 and ALDH2 were detected, and the correlation between Mfn2, ALDH2 and CHF was analyzed.

ResultsCompared with the control group, the serum levels of Mfn2, ALDH2 and LVEF decreased, the serum levels of NT-proBNP and LVEDD increased in the CHF group, and the differences of which were statistically significant(P < 0.01).Among the class Ⅱ, Ⅲ and Ⅳ heart function groups, the serum levels of Mfn2 and ALDH2 decreased with the decreasing of heart function, the serum levels of NT-proBNP and LVEDD increased with the increasing of heart function, and the differences of which were statistically significant(P < 0.01).According to the LVEF classification, the serum levels of Mfn2 and ALDH2 in patients with LVEF ≤ 40% were lower than those in patents with LVEF>40%, and the levels of NT-proBNP and LVED in patients with LVEF ≤ 40% were higher than those in patents with LVEF>40%(P < 0.05 to P < 0.01).The results of Pearson correlation analysis showed that the level of Mfn2 was negatively correlated with LVEDD(P < 0.01), and positively correlated with LVEF(P < 0.01), while the level of ALDH2 was positively correlated with LVEF(P < 0.01).The area under ROC curve of Mfn2, ALDH2 and both combination in the diagnosis of CHF were 0.803, 0.831 and 0.891(P < 0.05).

ConclusionsWith the decreasing of cardiac function in CHF patients, the serum levels of Mfn2 and ALDH2 decrease.The Serum levels of Mfn2, ALDH2 are related to the CHF, which may play an important role in clinical assessment and diagnosis.