Effect of limited resuscitation with sodium bicarbonate Ringer's solution on the internal environment of traumatic hemorrhagic shock

ObjectiveTo compare the effects of limited resuscitation with sodium lactate Ringer's solution and sodium bicarbonate Ringer's solution on peripheral blood cytokines, arterial blood lactate, platelet count and coagulation function in patients with traumatic hemorrhagic shock, to provide reference for screening relatively ideal resuscitation fluid.

MethodsIn a prospective controlled study, 48 inpatients with traumatic hemorrhagic shock were selected and divided into observation group and control group using random number table method (24 cases in each group).Sodium bicarbonate Ringer's solution was used for resuscitation in the observation group, sodium lactate Ringer's solution was used in the control group, and limited fluid resuscitation strategy was used in both groups.The levels of interleukin (IL)-4, IL-6, IL-10, tumor necrosis factor (TNF)-α in peripheral blood and arterial blood lactate value, peripheral platelet count, plasma prothrombin time and fibrinogen level were measured before resuscitation and 1 hour after resuscitation.

ResultsOne hour after resuscitation, except TNF-α, the other factors in observation group were significantly higher than those before resuscitation (P < 0.01), while only IL-6 and IL-10 in control group were significantly higher than those before resuscitation (P < 0.01);the levels of IL-4 and IL-10 in peripheral blood in observation group were higher than those in control group, while the levels of IL-6 and TNF-α in observation group were lower than those in control group (P < 0.05);the level of arterial blood lactate in observation group was significantly lower than that in control group (P < 0.01), but there was no significant difference in platelet count, plasma prothrombin time and fibrinogen level(P>0.05).

ConclusionsEarly resuscitation with sodium bicarbonate Ringer's solution in patients with traumatic hemorrhagic shock can better inhibit the expression of inflammatory factors in peripheral blood and reduce the blood lactate value, which is better than sodium lactate Ringer's solution for resuscitation.