ObjectiveTo investigate the effects of high frequency repetitive transcranial magnetic stimulation(rTMS) on the executive function in patients with methamphetamine dependence.
MethodsForty male patients with methamphetamine dependence were randomly divided into the observation group and control group(20 cases in each group), and intervened with high frequency rTMS and sham stimulation, respectively.The executive function in two groups before and after intervention were measured by behavior rating inventory of executive function-adult version(BRIEF-A) and stroop color word test(SCWT).
ResultsBefore intervention, the differences of the BRIEF-A total score, each factor score, average reaction time and correct reaction of SCWT between two groups were not statistically significant(P>0.05).After intervention, the BRIEF-A total score, each factor score and average reaction time of SCWT in observation group were lower than those in control group and before intervention(P < 0.05 to P < 0.01), and the correct reaction of SCWT in observation group was higher than that in control group and before intervention(P < 0.01).The differences of the BRIEF-A total score, each factor score, average reaction time and correct reaction of SCWT in control group between before and after intervention were not statistically significant(P>0.05).
ConclusionsThe high frequency rTMS can significantly improve the executive function in patients with methamphetamine dependence.
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