Relationship between IL-32 expression and prognosis of esophageal squamous cell carcinoma after radiotherapy

ObjectiveTo investigate the expression level of interleukin(IL)-32 in esophageal squamous cell carcinoma, and its relationship with the curative effects after radiotherapy.

MethodsThe clinical data of 95 patients with esophageal squamous cell carcinoma were retrospectively analyzed.The expression levels of IL-32 in patients with esophageal squamous cell carcinoma were detected using immunohistochemistry.According to the expression level of IL-32, the patients were divided into the high expression group(41 cases) and low expression group(54 cases).The clinical features and prognosis were compared between two groups.

ResultsThere was no statistical significance in the gender, age, tumor location and chemotherapy between two groups(P>0.05), while the difference of the tumor differentiation degree between two groups was statistically significant(P < 0.05).The results of Kaplan-Meier survival analysis showed that the difference of the prognosis between two groups was statistically significant(P < 0.05).The results of Cox multivariate analysis showed that the combined chemotherapy and high expression of IL-32 were the independent influencing factors of prognosis in patients with esophageal squamous cell carcinoma(P < 0.05).

ConclusionsThe high expression of IL-32 is an independent risk factor of prognosis in patients with intermediate esophageal squamous cell carcinoma after radiotherapy.