Differential expression of HES1 and HER2 and analysis of clinicopathological features between accessory breast cancer and routine mammary cancer

ObjectiveTo investigate the differences in the expression of hairy and enhancer of split 1(HES1) and human epidermal growth factor receptor 2(HER2) in accessory breast cancer(ABC) and routine mammary cancer(MC) and their relationship with clinicopathological features.

MethodsThe clinical data, pathological data, expression of HES1 and HER2 in cancer tissues and follow-up data of 30 patients with ABC and 30 patients with MC were analyzed retrospectively and evaluated statistically.

ResultsThe positive expression rates of HES1 and HER2 in ABC group were 30.00% and 53.33%, respectively, which were 40.00% and 40.00% in MC group, respectively, and the difference of which was not statistically significant(P>0.05).There were significant differences in the positive expression rate of HES1 between ABC group and MC group in different pathological type, histological grades, clinical stage, lymph node metastasis and triple negative breast cancer(P < 0.05 to P < 0.01).The positive expression rate of HES1 in ABC group was also statistically significant between patients with recurrence or not(P < 0.05).The positive expression rate of HER2 in ABC patients was statistically significant among different pathological type, histological grade, clinical stage, triple negative breast cancer and recurrence or not(P < 0.05 to P < 0.01).The positive expression rate of HER2 in MC patients was statistically significant among different pathological type, clinical stage, lymph node metastasis or not and triple negative breast cancer(P < 0.01).

ConclusionsThe positive expression rates of HES1 and HER2 before surgery can reflect the pathological features of ABC and MC patients to a certain extent, and provide reference for the selection of reasonable surgical plans.