Analysis of the clinical effects of heated humidified high-flow nasal cannula and non-invasive ventilation in the treatment of chronic obstructive pulmonary disease

ObjectiveTo compare the clinical effects between high-flow nasal cannula(HFNC) and non-invasive ventilation(NIV) in the treatment of acute exacerbations of chronic obstructive pulmonary disease(AECOPD) complicated with type Ⅱ respiratory failure.

MethodsSeventy-seven patients with COPD were randomly divided into the observation group(39 cases) and control group(38 cases).The observation group and control group were treated with HFNC and NIV, respectively.Two groups were treated with anti-inflammatory, spasmolysis, asthma and phlegm of comprehensive treatment.The blood gas analysis, CAT score, lung function and failure rate in two groups were compared between before and after treatment.

ResultsThe PaCO₂ and PaO₂ in two groups after 24 h of treatment were lower higher than those before treatment(P < 0.05), and the PaCO₂ and PaO₂ after 72 h of treatment were lower and higher than those before treatment and after 24 h of treatment, respectively(P < 0.05).There was no statistical significance in the levels of pH, PaCO₂ and PaO₂ in two groups between before and after treatment(P>0.05).After treatment, the differences of the failure rate, CAT score, pulmonary function indexes(including the FEV1, FVC and FEV1/FVC) and failure causes(including treatment intolerance, deterioration of blood gas indexes and exacerbation of clinical symptoms) were not statistically significant between two groups(P>0.05).

ConclusionsThe effects of HFNC and NIV in the treatment of AECOPD with type Ⅱ respiratory failure are similar.