The value of the levels of alpha-fetoprotein, free estriol, inhibin A and uterine arterial pulse index in predicting preeclampsia of pregnant women in the first and second trimesters of pregnancy

ObjectiveTo analyze the value of the individual and combined the levels of alpha-fetoprotein(AFP), free estriol(uE3), inhibin A(InhA) and uterine arterial pulse index(PI) in predicting preeclampsia of pregnant women in the first and second trimesters of pregnancy.

MethodsA total of 1 000 singleton primiparas were selected, 945 pregnant women diagnosed by preeclampsia were set as the case group, and the case group was matched to the control group in a ratio of 1:4 among pregnant women without preeclampsia.The serim levels of AFP, uE3 and InhA, and PI were detected and recorded.

ResultsThe incidence rate of preeclampsia in 945 pregnant women was 3.5%(33/945).There was no statistical significance in the AFP level between two group(P>0.05).The value of InhA and PI in case group were higher than those in control group, and the uE3 value in case group was lower than that in control group(P<0.05 to P<0.01).The sensitivities of InhA, uE3 and PI in predicting preeclampsia of pregnant women were 48.4%, 72.7% and 57.6%, respectively.The specificities of InhA, uE3 and PI in predicting preeclampsia of pregnant women were 78.0%, 69.7% and 84.8%, respectively.The sensitivity and specificity of the combined index for predicting preeclampsia were 75.8% and 76.5%, respectively.The area under the ROC curve of the combined data in predicting preeclampsia was 0.825, which was significantly higher than that of InhA, uE3 and PI, respectively(P<0.05).

ConclusionsThe combined value of uE3, InhA and PI in predicting preeclampsia is better than that of single parameter in the first and second trimesters of pregnancy.