Diagnostic value of urine podocalyxin level combined with serum inflammatory factors in diabetic nephropathy complicated with hyperuricemia

ObjectiveTo investigate the application value of urinary podocalyxin(PCX) combined with serum inflammatory factors in the diagnosis of diabetic nephropathy complicated with hyperuricemia.

MethodsOne hundred and six patients with diabetic nephropathy were divided into the diabetic nephropathy group(52 cases) and diabetic nephropathy complicated with hyperuricemia group(54 cases).Under the same conditions, the urine and blood tests were implemented in two groups.The urine PCX levels, and serum levels of C-reactive protein(CRP), tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), monocyte chemotactic protein-1(MCP-1) and myeloperoxidase(MPO) were compared between two groups.

ResultsThe levels of PCX, CRP, TNF-α, IL-6 and MCP-1 in diabetic nephropathy complicated with hyperuricemia group were higher tahn those in diabetic nephropathy group(P < 0.01), and the difference of MPO level between two groups was not statistically significnat(P>0.05).The results of binary logistic regression analysis showed that the urine PCX, serum CRP, TNF-α, IL-6 and MCP-1 were the independent risk factors of diabetic nephropathy complicated with hyperuricemia, and closely related to diabetic nephropathy complicated with hyperuricemia.The area under the ROC curve of combined detection of PCX, CRP, TNF-α, IL-6 and MCP-1 was better than that of each index alone(P < 0.05 to P < 0.01), and the sensitivity and specificity of combined detection of PCX, CRP, TNF-α, IL-6 and MCP-1 and MCP-1 were better than those of individual diagnosis(P < 0.05).

ConclusionsThe urine PCX level combined with serum inflammatory factors(CRP, TNF-α, IL-6 and MCP-1) have high diagnostic value for diabetic nephropathy complicated with hyperuricemia, and broad prospect of clinical application.