ObjectiveTo explore the related factors of the recurrence within 2 years of precancerous lesions of cervical cancer after cervical loop electrosurgical excision procedure(LEEP).
MethodsThe clinical data of 458 patients with precancerous lesions of cervical cancer were retrospectively analyzed.The LEEP surgery in all patients was successfully completed.After 2 years of postoperative following-up, 31 patients were set as relapsed group, and the remaining 427 patients were set as non-relapsed group.The relapse of patients was analyzed after LEEP, and the risk factors of the recurrence of cervical precancerous lesion within 2 years after LEEP were analyzed.
ResultsAmong the 458 patients, 31 cases relapsed within 2 years of following-up, the cure rate and recurrence rate were 93.23% and 6.77%, respectively.Six cases, 8 cases and 17 cases recurred within 6 months, 6 months to 1 year and 1 to 2 years after operation, respeectively.The mean recurrence time was(15.53±4.23) months.The differences of the age, menopause, smoking, involvement of cervical duct, quadrant involvement, preoperative HR-HPV RLU/CO, surgical margin and postoperative persistent infection of same type HPV between two groups were statistically significant(P < 0.05 to P < 0.01).The results of logistic multivariate analysis showed that advanced age, menopause, involvement of cervical duct, preoperative HR-HPV RLU/CO ≥ 1 000, positive surgical margin and postoperative persistent infection of the same type HPV were the risk factors of recurrence within 2 years of precancerous lesions of cervical cancer after LEEP(P < 0.05 to P < 0.01).
ConclusionsThe recurrence rate of precancerous lesions of cervical cancer within 2 years after LEEP surgery is 6.77%, and the advanced age, menopause, involvement of cervical duct, preoperative HR-HPV RLU/CO ≥ 1 000, positive incisal margin and postoperative persistent infection of the same type HPV can increase the recurrence rate.Therefore, the clinical monitoring should be strengthened.
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