Application value of multi-parameter 3.0T-MRI in HER-2 positive breast cancer

ObjectiveTo explore the clinical value of multi-parameter 3.0T-MRI in the diagnosis of human epidermal growth factor receptor 2(HER-2)positive breast cancer.

MethodsThe imaging features and clinical data of 74 patients with breast cancer confirmed by pathology were retrospectively analyzed.The breast MRI in all patients were detected before operation.According to the expression of HER-2 detected by postoperative pathological immunohistochemistry, the patients were divided into the HER-2 positive group(34 cases) and HER-2 negative group(40 cases).The differences of the age, length, diameter, shape and edge of lesions, enhancement mode, apparent diffusion coefficient(ADC) value and time-intensity curve(TIC) curve were compared between two groups, and the MRI features of the HER-2 positive breast cancer were analyzed.

ResultsThe difference of the age between the HER-2 positive group(49.59±9.30) years old and HER-2 negative group(45.68±9.01) years old was not statistically significant(P>0.05).The ADC value of lesions in HER-2 positive group(1.01±0.23)×10^-3mm²/s was higher than that in HER-2 negative group(0.90±0.16)×10^-3mm²/s(P < 0.05), and the area under ROC curve(AUC) was 0.663(95%CI: 0.538-0.789).The ring enhancement patterns of lesions in HER-2 positive group was more than that in HER-2 negative group(P < 0.01), and AUC was 0.689(95%CI: 0.567-0.811).The differences of the length, diameter, shape and edge of lesions, and MRI characteristic parameters of TIC curve were not statistically significant between two groups(P>0.05).

ConclusionsThe MRI findings of the HER-2 positive breast cancer have certain characteristics, which can provide an important reference for the preoperative evaluation, clinical treatment and prognosis of patients.