ObjectiveTo evaluate the clinical curative effects of endoscopic varices ligation(EVL) and tissue adhesive combined with sclerosing agent injection in the treatment of esophageal and gastric varices in patients with cirrhosis.
MethodsEighty-three patients treated with esophageal and gastric varices were selected, and divided into the EVL group(42 cases treated with endoscopic varices ligation), and combined group(41 cases treated with tissue adhesive combined with sclerosing agent injection).The short-term complications in two groups after treatment were observed, and the reduction of esophageal and gastric varices after 1 and 6 months of treatment was reexamined using gastroscopy.
ResultsThe incidence rates of choking sensation and local ulcer in combined group were higher than those in EVL group, and the incidence rate of throat pain in combined group was lower than that in EVL group(P < 0.05).The differences of the incidence rates of fever, recent bleeding and chest pain were not statistically significant between two groups(P>0.05).The results of the gastroscopy reexamination after 1 month showed that the total effective rates of improvement of the varices of esophagus and stomach fundus in the combined group and EVL group were 80.5% and 85.7%, respectively, and the difference of which was not statistically significant(P>0.05).The results of the gastroscopy reexamination after 6 months showed that the total effective rates of improvement of the varices of esophagus and stomach fundus in the combined group and EVL group were 87.9% and 69.1%, respectively, and the difference of which was statistically significant(P < 0.05).
ConclusionsThe endoscopic varices ligation and tissue adhesive combined with sclerosing agent injection can effectively alleviate the esophageal and gastric varices.The long-term therapeutic effect of tissue adhesive combined with sclerosing agent injection is superior to endoscopic varices ligation.
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