Correlation between the levels of urinary AD7C-NTP and serum C-reactive protein and vascular mild cognitive dysfunction in elderly patients with lacunar cerebral infarction

ObjectiveTo analyze the correlation between the levels of urinary Alzheimer's disease-related neurofilament protein(AD7C NTP) and serum C-reactive protein(CRP), and vascular mild cognitive impairment in elderly patients with lacunar cerebral infarction.

MethodsTwo hundred and sixty-eight elderly patients with lacunar cerebral infarction were selected as the research objects.Among them, 117 patients with vascular mild cognitive impairment and other 151 patients were divided into the observation group and control group, respectively.The demographic characteristics, past medical history, AD7C NTP, CRP and other biochemical indicators were recorded, and the scores of Montreal Cognitive Assessment Scale(MoCA), CAMCOG-C and MMSE, and other clinical data in two groups were analyzed.

ResultsThe proportion of male patients, proportion of diabetes history, and the concentrations of triglyceride, AD7C-NTP and CRP in observation group were higher than those in control group(P < 0.05 to P < 0.01).The MOCA score, CaMCOG-C score and MMSE score in observation group were lower than those in control group(P < 0.05).The results of multivariate logistic regression analysis showed that diabetes history, levels of AD7C-NTP and CRP increasing were the risk factors of cognitive impairment in elderly patients with lacunar cerebral infarction(P < 0.05 to P < 0.01).The results of correlation analysis showed that the levels of AD7C-NTP and CRP were significantly negatively correlated with MOCA score(r=-0.717, -0.656, P < 0.01).

ConclusionsThe levels of AD7c-NTP and CRP are positively correlated with cognitive impairment in elderly patients with lacunar infarction.Early monitoring of AD7c-NTP and CRP indicators can help predict the vascular mild cognitive dysfunction, so as to achieve early diagnosis and early treatment.